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INDENO1,2-CPYRAZOL-4-ONE DERIVATIVES USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
INDENO1,2-CPYRAZOL-4-ONE DERIVATIVES USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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机译:可用作抗癌剂的茚并[1,2-C]吡唑-4-酮衍生物和包含它们的抗增殖剂和药物组合物
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摘要
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
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