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TUMOR SUPPRESSOR GENE, PROTEIN EXPRESSED THEREBY, VECTORS CONTAINING SAID GENE, AND USE OF SAID VECTOR AND PROTEIN IN CANCER TREATMENT
TUMOR SUPPRESSOR GENE, PROTEIN EXPRESSED THEREBY, VECTORS CONTAINING SAID GENE, AND USE OF SAID VECTOR AND PROTEIN IN CANCER TREATMENT
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机译:肿瘤抑制基因,由此表达的蛋白质,含有所述基因的载体,以及所述的向量和蛋白质在癌症治疗中的用途
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摘要
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94RB expression vector or an effective amount of p94RB protein into a cell or cells in need of treatment.
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