首页> 外国专利> Pharmaceutical composition containing calcium carbonate or mixture thereof with magnesium hydroxycarbonate or with vitamin D, used for prophylaxis or treatment of osteoporosis

Pharmaceutical composition containing calcium carbonate or mixture thereof with magnesium hydroxycarbonate or with vitamin D, used for prophylaxis or treatment of osteoporosis

机译:含有碳酸钙或其与羟基碳酸镁或维生素D的混合物的药物组合物,用于预防或治疗骨质疏松症

摘要

The invention refers to medicine, namely to a pharmaceutical composition that may be used for prophylaxis and treatment of osteoporosis.Summary of the invention consists in that the pharmaceutical composition contains calcium carbonate or mixture thereof with magnesium hydroxycarbonate or with vitamin D, where to a dose of calcium of 150…1500 mg, preferably of 200…600 mg, may be taken 100…1000 IU, preferably 400…900 IU of vitamin D, or 20…500 mg, preferably 150…300 mg of magnesium, wherein the active substances containing calcium and magnesium are finely grounded so that at least 80% of particles have dimensions under 75 µm and, moreover, contain conventional adjuvants and pharmaceutically acceptable derivatives of starch, preferably diphosphate starch in a quantity of 5…40 wt%, preferably of 15…25 wt%; substances of vegetal origin able to form xerogels with the water, preferably carragheenan, in a quantity of 0,1…1,0 wt%, preferably of 0,2…0,6 wt%.The aforesaid composition represents a quick-soluble powder, which at the addition of liquids, after a short mixing, form a pudding resembling gellylike suspension, well-tolerated by patients.
机译:本发明涉及药物,即可以用于预防和治疗骨质疏松症的药物组合物。本发明的概述在于,该药物组合物包含碳酸钙或其与羟基碳酸镁或维生素D的混合物,可以服用100…1000 IU,优选400…900 IU的维生素D 150…1500 mg,优选200…600 mg钙,或20…500 mg,优选150…300 mg镁,其中活性物质含钙和镁的粉末被细磨,以使至少80%的颗粒尺寸在75 µm以下,此外,还包含常规的佐剂和淀粉的药学上可接受的衍生物,优选5…40 wt%,优选15重量%的二磷酸淀粉…25 wt%;能够与水形成干凝胶的植物来源物质,优选角叉菜胶的量为0.1 ... 1,0 wt%,优选为0.2 ... 0.6 wt%。上述组合物为速溶粉末短时间混合后,在添加液体后会形成类似凝胶状悬浮液的布丁,患者可以很好地耐受。

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