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PREPARATION OF WARFARIN SODIUM FROM WARFARIN SODIUM-2-PROPANOL CLATHRATE BY SOLVENT EXPULSION.
PREPARATION OF WARFARIN SODIUM FROM WARFARIN SODIUM-2-PROPANOL CLATHRATE BY SOLVENT EXPULSION.
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机译:溶剂萃取法从沃拉林-2-丙醇包合物中制备沃拉林钠。
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摘要
The present invention is a method for producing warfarin sodium from warfarin sodium 2-propanol clathrate by thermal, nondestructive solvent expulsion. The solvent expulsion is conducted under conditions of controlled heat transfer whereby the 2-propanol is expelled from the warfarin sodium 2-propanol clathrate without decomposition of warfarin sodium or the clathrate. Heating is conducted the clathrate at a temperature from about 100 C to about 170 C in an active oven under air or in an inert atmosphere and at partial pressures ranging from that of a relative vacuum to atmospheric pressure. The invention also relates to pure warfarin sodium prepared according to the method of the invention and pharmaceutical compositions containing warfarin sodium.
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