TRANSGENIC NON-HUMAN MAMMALS EXPRESSING CONSTITUTIVELY ACTIVATED TYROSINE KINASE RECEPTORS.

摘要

A transgenic non-human mammal whose germ cells and somatic cells contain a constitutively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-independent in vivo models for the identification and development of selective tyrosine kinase modulators for the treatment of cancer.