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Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3)

机译：GTP-14564的选择性细胞毒理机制，一种表达组成型活性FMS酪氨酸激酶3（FLT3）的白血病细胞中的新型酪氨酸激酶抑制剂

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Ken Murata; Hidetoshi Kumagai; Toshiyuki Kawashima; Kaori Tamitsu; Mariko Irie; Hideaki Nakajima; Shinya Suzu; Masabumi Shibuya; Shimeru Kamihira; Tetsuya Nosaka; Shigetaka Asano; Toshio Kitamura;
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1. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms [J] . Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, Haematologica . 2017,第12期

机译：Anexelekto / MER酪氨酸激酶抑制剂ONO-7475通过多种机制阻止生长并杀死FMS样酪氨酸激酶3内部串联复制突变型急性髓系白血病细胞
2. Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia [J] . Liang Xiaofei, Wang Beilei, Chen Cheng, Journal of Medicinal Chemistry . 2019,第2期

机译：发现N-（4-（6-乙酰胺嘧啶-4-基氧基）苯基）-2-（2-（三氟甲基）苯基）乙酰胺（CHMFL-FLT3-335），作为有效的FMS样酪氨酸激酶3内部串联复制（ FLT3-ITD）突变选择性抑制剂用于急性髓性白血病
3. Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. [J] . Fischer T, Stone RM, Deangelo DJ, Journal of Clinical Oncology . 2010,第28期

机译：IID期口服Midostaurin（PKC412），FMS样酪氨酸激酶3受体（FLT3）和多靶点激酶抑制剂的临床试验，用于患有急性髓样白血病和高危骨髓增生异常综合征的野生型或突变型FLT3患者。
4. Taking Quinazoline as a General Support-Nog to Design Potent and Selective Kinase Inhibitors: Application to FMS-like Tyrosine Kinase 3 [C] . Wei-Wei Li, Luo-Ding Yu, Li-Juan Chen, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：以喹唑啉作为一般支持物来设计有效和选择性激酶抑制剂：在类似FMS的酪氨酸激酶3中的应用
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms [O] . Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, 2017

机译：Anexelekto / MER酪氨酸激酶抑制剂ONO-7475通过多种机制阻止生长并杀死FMS样酪氨酸激酶3内部串联复制突变型急性髓细胞白血病细胞
7. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms [O] . Peter P. Ruvolo, Huaxian Ma, Vivian R. Ruvolo, 2017

机译：Anexelekto / MER酪氨酸激酶抑制剂ONO-7475通过各种机制抑制生长和杀死FMS样酪氨酸激酶3内部串联复制突变体急性髓性白血病细胞

Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3)

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