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Process for preparing epimerized derivatives of k5polysaccharide with a very high degree of sulfati on and new epi k5-n,o-sulfated polysaccharide derivatives
Process for preparing epimerized derivatives of k5polysaccharide with a very high degree of sulfati on and new epi k5-n,o-sulfated polysaccharide derivatives
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机译:高度硫化的k5多糖的差向异构化衍生物的制备方法和新的e5-k5-n,o-硫酸化多糖衍生物
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摘要
A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
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