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Process for preparing epimerized derivatives of k5polysaccharide with a very high degree of sulfati on and new epi k5-n,o-sulfated polysaccharide derivatives
Process for preparing epimerized derivatives of k5polysaccharide with a very high degree of sulfati on and new epi k5-n,o-sulfated polysaccharide derivatives
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机译:高度硫化的k5多糖的差向异构化衍生物的制备方法和新的e5-k5-n,o-硫酸化多糖衍生物
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摘要
LMW-K5-N,O-oversulfates are described, having a sulfation degree of from 3.2 to 4 and a mean molecular weight of from about 3,000 to about 6,000, obtainable by depolymerization of corresponding K5-N,O-oversulfates or starting from LMW-K5-N-sulfates by O-oversulfation of a tertiary amine or quaternary ammonium salt thereof and subsequent N-resulfation of the K5-amine-O-oversulfate thus obtained. Furthermore, pharmaceutical compositions containing these LMW-K5-N,Ooversulfates having antiangiogenetic and antiviral, in particular anti-HIV-1 activity. Intermediate LMW-K5-N-sulfates are also described.
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