Production of recombinant adenovirus, useful in gene therapy and genomics, by homologous recombination between parent and shuttle

摘要

Compositions and methods for preparing recombinant adenoviruses are described. The resulting adenoviruses can be used for transferring and/or expressing genes in cells, in vitro, or ex vivo, or also in functional genomics. More particularly, efficient methods for producing adenovirus banks and the use of said banks in functional genomics are described. Further described are plasmids used for constructing the adenoviruses.