Low dose entecavir formulation and usein treating hepatitis B virus infection

摘要

Entecavir can be used in the manufacture of a medicament comprising entecavir in the low dose amount of about 0.1mg to 5mg for once a day administration to treat hepatitis B virus infection. Pharmaceutical composition for oral administration comprise from about 0.001mg to about 10mg of entecavir adhered to a carrier substance, which is preferably selected from lactose, microcrystalline cellulose, calcium phosphate, dextrin, dextrose, detrates, mannitol, sorbitol and sucrose. Also described is a method for making an oral entecavir pharmaceutical composition, comprising 0.001 to about 10% entecavir on a weight/weight basis of the composition wherein a solution comprising the entecavir is sprayed onto a pharmaceutically acceptable carrier substrate and then drying the coated carrier substrate to remove the water.