High dose therapeutic combination of amlodipine and benazepril

摘要

A combination of an angiotensin converting enzyme inhibitor (ACEI) selected from benazepril and benzaprilat and a calcium channel blocker, amlodipine, can be used in the manufacture of a medicament for treating or preventing hypertension congestive heart failure, angina, myocardial infarction, atherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood-pressure-related cerebrovascular disease, stroke, pulmonary disease, pulmonary hypertension and headache, wherein the amount of amlodipine corresponds to 10mg of free base and the amount of the ACE inhibitor corresponds to 20mg to 160mg of benzepril hydrochloride.