PROSTAGLANDIN ANALOGUES_AS EP4 RECEPTOR AGONISTS

摘要

This invention relates to compounds which are generally EPSUB4 /SUBreceptor agonists and which are represented by Formula I: wherein A is a -CHSUB2/SUB-CHSUB2/SUB-, or -CH-CH-; B is absent, an aryl, or heteroaryl group; RSUP1 /SUPis alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and RSUP3/SUP, RSUP4/SUP, RSUP5 /SUPand RSUP6 /SUPare not simultaneously hydrogen, or RSUP1 /SUPis heterocyclylalkyl, aryl, or heteroaryl when B is absent and RSUP3/SUP, RSUP4/SUP, RSUP5 /SUPand RSUP6 /SUPare simultaneously hydrogen; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.