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Method of preparation of medicines for inalacao continues
Method of preparation of medicines for inalacao continues
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机译:制备用于inalacao的药物的方法继续
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摘要
New method for continuous production of an inhalable medicament comprises: (A) segmenting a drug solution using a segmenter and a transport medium; (B) carrying out crystallization in a holding region at defined temperature; and (C) separating the crystals from the supernatant in separator after passing through the holding region. New method for continuous production of an inhalable medicament comprises: (1) segmenting a drug solution using a segmenter and a transport medium; (2) carrying out crystallization in a holding region at defined temperature, by firstly inducing seed formation by a sudden reduction in temperature (such that the solution reaches a supersaturated, metastable or labile state) then causing crystal growth by targeted cooling; and (3) separating the crystals from the supernatant in separator after passing through the holding region. Independent claims are also included for: (a) a microreactor for carrying out the process, consisting of a micromixer, a segmenter and a holding region, where: the dimensions of the micromixer for distribution of the supplied fluids to be mixed are 10-1000 (preferably 25-200) Microm; the dimensions of the channel of the segmenter are 0.1-5 (preferably 0.2-5) mm; and the holding region is a tube, pipe or channel of diameter 0.5-10 (preferably 1-2) mm and length 0.1-200 (preferably 1-25) m; and (b) an inhalable medicament having an aerodynamic diameter of less than 20 (preferably 0.3-5) Microm, obtained by the process. ACTIVITY : Antiallergic; Anticholinergic. No biological data available. MECHANISM OF ACTION : beta -Sympathetic mimetic. No biological data available.
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