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Platinum complex in oxidation number IV, process for its preparation, this complex as medicament and pharmaceutical composition containing this complex

机译:氧化数为IV的铂配合物,其制备方法,该配合物作为药物和含有该配合物的药物组合物

摘要

Platinum complex of general formula (I). There is also disclosed a process for the manufacture of the complex of formula (I) based on oxidation of a complex of divalent platinum of formula (II) with hydrogen peroxide and on optional substitution of hydroxyl groups in the obtained product with carboxylate groups by action of an acylating agent. The disclosed complexes may be used as such or as a part of pharmaceutical compositions in a therapy of oncological diseases.
机译:通式(I)的铂络合物。还公开了基于式(II)的二价铂的配合物与过氧化氢的氧化,以及通过作用将所得产物中的羟基任选地用羧酸酯基取代来制备式(I)的配合物的方法酰化剂。所公开的复合物可以本身或作为药物组合物的一部分用于肿瘤疾病的治疗。

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