PCT No. PCT/GB93/01632 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Aug. 3, 1993 PCT Pub. No. WO94/03614 PCT Pub. Date Feb. 17, 1994Serine proteases of the chymotrypsin superfamily are modified so that they exhibit resistance to serine protease inhibitors. If such modified serine proteases have fibrinolytic, thrombolytic, antithrombotic or prothrombotic properties, they are useful in the treatment of blood clotting diseases or conditions.
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