VECTOR CONSTRUCTS FOR THE GENTHERAPEUTICALLY MEDIATED RADIONUCLIDE THERAPY OF DIFFERENTIATED AND MEDULAR THYROID CARCINOMAS AND NON-THYREOIDAL TUMORS AND THEIR METASTASES

摘要

The invention relates to vector constructs, comprising vector DNA which includes regulatory sequences, the NIS gene coding for the sodium/iodide symporter, the TPO gene coding for thyroidal peroxidase and use thereof for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states, whereby treatment occurs before or concurrent with a radionuclide therapy, in particular, with iodine-131, or astatine-211. The invention further relates to use of two or several vector constructs for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states.