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MUTANT ANTHRAXTOXIN PROTECTIVE ANTIGEN PROTEINS SPECIFIC FOR CELLS CONTAINING HIGH CELL SURFACE METAL METROPROTEIN NOSE OR PLASMINOGEN ACTIVATOR RECEPTOR AMOUNT
MUTANT ANTHRAXTOXIN PROTECTIVE ANTIGEN PROTEINS SPECIFIC FOR CELLS CONTAINING HIGH CELL SURFACE METAL METROPROTEIN NOSE OR PLASMINOGEN ACTIVATOR RECEPTOR AMOUNT
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机译:特定于含有高细胞表面金属蛋白鼻或纤溶酶原激活物受体的细胞的突变型抗人毒素保护抗原蛋白
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摘要
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
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