Methods and apparatus for identifying programs genomic regions harboring an associated with a detectable trait gene.

摘要

A method for confirming or determining whether a candidate genomic region harbors a number associated with a detectable trait comprising the steps of gene: build a distribution of a suspicious candidate region of test values ​​using a plurality of biallelic markers in a candidate genomic region of harboring said gene associated with said detectable trait, said distribution of the candidate region of values ​​indicative test of the difference in the frequencies of said plurality of biallelic markers in said candidate region in unrelated individuals who possess said detectable trait and control individuals who possess said detectable trait not; building a distribution of a random region of test values ​​using a plurality of biallelic markers in random genomic regions which are not suspected of harboring said gene associated with said detectable trait, said distribution of the random region of the test values ​​indicative of the difference in the frequencies of said plurality of biallelic markers in said random genomic regions in unrelated individuals who possess said detectable trait and control individuals who do not possess said detectable trait; and determining whether said candidate region distribution of test values ​​and said random region distribution of test values ​​are significantly different from each other, to determine whether the candidate region likely to contain a gene associated with the detectable trait.