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SUSTAINABLE ACTIVE PRINCIPLE SUSTAINED RELEASE SYSTEMS.
SUSTAINABLE ACTIVE PRINCIPLE SUSTAINED RELEASE SYSTEMS.
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机译:可持续的主动原则持续发布系统。
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摘要
Implantable active principle sustained release system composed of - a glycerin monoolein lipid matrix that can form cubic phases, in which - lipid molecules with charged head groups and / or occupying space from the steric point of view are incorporated, as modifying molecules, whereby the modifying molecules carry the negatively charged head group 1,2-dimiristoyl glycerophosphatidic acid (DMPA, Na salt) or amphiphilic molecules with PEG head groups are used as modifying molecules, and the - Pharmaceutically effective substances contain carboplatin, oxaliplatin, taxol, daunorubicin, mitoxantron, gencitabine, topotecan, campotecin, peptides, gene therapy agents such as DNA, RNA, oligonucleotides or ribozymes.
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