INHIBITORS OF THE 3 ', 5'-PHOSPHODESTERASE CYCLAN GUANOSINE MONOPHOSPHATE.

摘要

A compound of ** formula ** or a pharmaceutically or veterinarily acceptable salt thereof, selected from formulas IA, IB, IC, ID and IE, in which X represents CH or N; R1, R2 and R3, when present and bound to nitrogen, independently represent H, C1-C6 alkyl, Het, (C1-C6) alkyl Het, aryl or (C1-C6) alkyl aryl; R1, R2 and R3, when present and bonded to carbon, independently represent H, halo-, cyano, nitro, OR6, OC (O) R6, C (O) R6, C (O) OR6, NR6C (O) NR7R8 , NR6C (O) OR6, OC (O) NR7R8, C (O) NR9R10, NR9R10, SO2NR9R10, SO2R11, C1-C6 alkyl, Het, (C1-C6) alkyl Het, aryl or (C1-C6) aryl; with the proviso that R3 does not represent H in formula IE when X is CH; with the proviso that in formula 1A or 1D, when X is N, R5 does not represent optionally substituted C1-C6 alkyl and / or terminated with one or more substituents selected from halo-, OR17, NR12R17 or NR17C (O) R17.