首页>
外国专利>
PREPARATION PROCEDURE FOR MIKANIA EXTRACTS CONTAINING MIKANOLIDA AND DIHYDROMIKANOLIDE AND USE IN THE TREATMENT OF PROLIFERATIVE DISEASES.
PREPARATION PROCEDURE FOR MIKANIA EXTRACTS CONTAINING MIKANOLIDA AND DIHYDROMIKANOLIDE AND USE IN THE TREATMENT OF PROLIFERATIVE DISEASES.
展开▼
机译:包含密克罗尼达和二氢吡喃内酯的米卡尼亚提取物的制备方法及其在治疗增生性疾病中的用途。
展开▼
页面导航
摘要
著录项
相似文献
摘要
Procedure for obtaining a dry extract of Mikania micrantha, Mikania scandens and Mikania cordata leaves comprising at least 50% by weight of mikanolide and dihydromikanolide and at least 20% of dihydromikanolide, said process being characterized in that it comprises the following successive stages: Crushed and dried leaves of Mikania micrantha, Mikania scandens and Mikania cordata; Addition, to the crushed sheets of Mikania micrantha, Mikania scandens and Mikania cordata, of a solvent chosen from toluene, ethyl acetate, mixtures of toluene and ethyl acetate, mixtures of toluene and acetone, mixtures of ethyl acetate and heptane, and mixtures of heptane and acetone in the proportions of 7: 3 to 3: 7; Filtration and filtration recovery; Concentration of the extract of the solution of the primary extract to obtain a concentration of 2.5 to 10% in dry extract; Partition of the concentrated extract obtained in the preceding stage between the extraction solvent and a mixture comprising 10% to 50% methanol or ethanol in water; ¿Washing of the alcohol ¿water phase with n¿hexane or heptane; ¿Elimination of alcohol from the alcohol phase ¿water; Extraction of the aqueous phase obtained with ethyl acetate; Drying of the ethyl acetate phase with a drying agent; Evaporation of solvents and recovery of dry extract; Purification of the dry extract obtained by a method of physical and chemical separation; and, after removal of solvents, obtaining the desired dry extract.
展开▼