New procedure for Synthesis of (2S, 3aS, 7aS) perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril.

摘要

Method for synthesizing compounds of formula ** ** in which R represents a hydrogen atom or a benzyl group or alkyl of 1 to 6 linear or branched carbon, and their addition salts with an acid or an inorganic base or organic. wherein the acid (2- oxocyclohexyl) acetic acid of formula which is condensed with (S) -phenylglycinol, in which Ph represents phenyl group, to yield the tricyclic lactam, in the form of a single diastereoisomer, in which Ph represents the phenyl group, which is reacted with a reducing agent in the presence of a Lewis acid, to yield a compound in which Ph represents the phenyl group, which function 2-hydroxy-1-phenylethyl is separated, that reacts either with triflic anhydride, or with an alkylating reagent.