Unlocking the common pathway of aromatic amino acid synthesis.

摘要

EFFICIENCY IMPROVED PRODUCTION OF AROMATIC ACROSS THE PATH COMMON AS SHOWN IN FIGURE 1 of a host cell TAKES PLACE THROUGH ENHANCING EXPRESSION OF SPECIES OF ENZYME ACTING ON INTERMEDIARY substrate STEPS rEACTION WITH SPEED LIMIT IDENTIFIED IN THE PATH. DESCRIBED prokaryotic cell transformants comprising DNA sequences encoding EXOGENOUS ENZYMES SPECIES, 3-DEHIDROQUINATO synthase, shikimate QUINASA, SYNTHASE 5-ENOLPYRUVOYLO-shikimate-3-phosphate synthase CLORISMATO. These transformants may also be transformed with DNA sequences encoding EXOGENOUS enzyme species transketolase and DAHP synthase. In one embodiment of the present invention, SE incorporate one or more DNA sequences encoding the enzyme species TRANSFORMING THE GENOME.