COMBINATION OF ATOVAQUONE WITH PROGUANIL FOR THE TREATMENT OF PROTOZOAL INFECTIONS

摘要

The invention relates to combinations of atovaquone and proguanil, their usein the treatment and prophylaxis of parasitic infections,such as protozoal parasitic infections, e.g. malaria and toxoplasmosis, andinfections caused by P.carinii and their use in the manufactureof medicaments for the treatment and/or prophylaxis of such infections. Thecombinations can conveniently be administered in a singlepharmaceutical formulation. Preferably, atovaquone and proguanil areadministered in a potentiating ratio so that they act in synergy.