UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS

摘要

A compound having formula (I) or a pharmaceutically acceptable salt thereof,wherein X and Z each independently are NH or CH2,at least one of X and Z being NH; Y is O, S, NCN, or NH; B, D, E and F eachindependently are C or N, at least three of B, D, E, and Fbeing C; and R1, R2, R3, R4, R11, R12 have the meanings set forth in thespecification, pharmaceutical compositions comprising the same,and a method of treating therewith. The compounds are useful as potassiumchannel openers.