2-PHENYL-2-(2'-PIPERIDINYLIDENE)ACETATE DERIVATIVE, PROCESS FOR MANUFACTURING THE SAME, AND PROCESS FOR MANUFACTURING OPTICALLY ACTIVE 2-PHENYL-2-(2'-PIPERIDINYL)ACETATE DERIVATIVE BY ASYMMETRICALLY HYDROGENATING THE SAME

摘要

Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetatederivative suitably used for a raw material of a2-phenyl-2-(2'-piperidinyl)acetate derivative and a process formanufacturing the same. Also disclosed is a process formanufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediatefor an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured bycyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoatederivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured byasymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of acomplex of a Group VIII transition metal or an acid.