COMPOSITION FOR STABILIZING SURVIVAL OF TRANSPLANTED HEMATOPOIETIC STEM CELL, KIT FOR OBTAINING THE COMPOSITION, METHOD OF STABILIZING SURVIVIAL OF TRANSPLANTED HEMATOPOIETIC STEMCELL, HUMAN MONOCLONAL ANTIBODY OR HUMAN POLYCLONAL ANTIBODY AND METHOD OF PRODUCING THE SAME, GENE ENCODING HUMAN MONOCLONAL ANTIBODY AND TRANSFORMATION INTRODUCING THE GENE

摘要

[PROBLEMS] To stabilize the survival of transplanted hematopoietic stem cellsby using HLA-matched activated lymphocytes. [MEANS FOR SOLVING PROBLEMS] HLA-matched activated lymphocytes in mononuclear cells separated from peripheralblood or umbilical cord blood are proliferated and activated. After separatingand collecting, the HLA-matched activated lymphocytes are employed as the maincomponent of a composition for stabilizing the survival of transplantedhematopoietic stem cells. The obtained composition is widely usable in, forexample, prevention of insufficient survival of transplanted hematopoieticstem cells and therapy for promoting the survival thereof. Although the doseof the composition varies depending on the age, conditions, etc. of a patient,a humanized antibody is administered in a dose of from 0.2 to 20 mg/kg/day tomammals including humans. The composition is administered by intravenousinjection either once a day (single administration or continuousadministration) or intermittently 1 to 3 times in a week or once in 2 or 3weeks.