SOLID DISPERSIBLE AND/OR ORODISPERSIBLE NON-FILMY CONTAINING AT LEAST ONE TYPE OF ACTIVE SUBSTANCE PHARMACEUTICAL COMPOSITION AND METHOD FOR THE PREPARATION THEREOF

摘要

The invention relates to an immediate release dispersible and orodispersible solid pharmaceutical composition having the form of particles with a size lower than 710 mum, containing the metformin active ingredient, characterized in that it comprises: a) from 65% to 90% in weight of the metformin active ingredient, optionally under the form of a salt, or a combination of the metformin active ingredient with a hypoglycemic active ingredient; b) from 0.5 to 4% in weight of a binding agent or a combination of binding agents; c) from 1% to 12% in weight of a disintegrating agent or a combination of disintegrating agents; d) from 0% to 10% in weight of a diluting agent or a combination of diluting agents; e) from 0.05% to 3% in weight of a sweetening agent or a combination of sweetening agents; and f) one or more additional excipients, the weight percentages being expressed based on the total weight of said composition.