USING MULTIPLE PERTURBATIONS TO ELUCIDATE CONNECTIVITY IN NETWORK SYSTEMS

摘要

One embodiment of the invention is a method of analyzing the effects ofcombined perturbers of a network system by means of a set of model predictionsfor various network configurations, using a set of phenomenologically-basedcombination surface models. This method can be used to predict the effects ofcombined perturbers of known networks, for example, providing mechanisticvalidation for therapeutic compounds. Alternatively, this method can provideconstraints for constructing connectivity models from observed combinationeffects on networks of unknown structure, thus, for example, providing therequired understanding to identify novel targets for therapeutic compounds.