MACROMOLECULAR DRUG COMPLEXES HAVING IMPROVED STABILITY AND THERAPEUTIC USE OF THE SAME

摘要

Macromoleculir drug complexes containing a protein therapeutic, like humangrowth hormone, and an excess stoichiometric molar amount of a polymer, likeheparin, and compositions containing the same, are disclosed. Compositionscontaining the macro~molecular drug complexes are administered, including viapulmonary delivery, to individuals suffering from a disease or condition, andthe complexes, re~lease the protein therapeutic, in vivo, to treat the diseaseor condition.