METHOD FOR DETERMINING SPECIFIC GROUPS CONSTITUTING HEPARINS OR LOW MOLECULAR WEIGHT HEPARINS USING REVERSED PHASE COLUMN CHROMATOGRAPHY

摘要

The invention provides methods for analysing heparins, low-molecular-weightheparins, ultralow-molecular-weight heparins, and oligosaccharides by highperformance liquid chromatography a stationary phase dynamically coated with aquaternary ammonium salt. The methods of the invention may be used to analysesamples without pre-treatment or to analyse samples that have been partiallyor exhaustively depolymerised and, optionally, reduced. Specific saccharidescan be detected.