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Inhibition of apoptosis-specific elF-5A ('elF-5A1') with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
Inhibition of apoptosis-specific elF-5A ('elF-5A1') with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
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机译:用反义寡核苷酸和siRNA抑制凋亡特异性elF-5A(“ elF-5A1”)作为抗炎药
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摘要
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
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