Methods involving induced dimerisation by cellular components

摘要

We describe a method of inducing a cell to generate a detectable signal. The method comprises the steps of providing a cell comprising an entity and providing a first reporter and a second reporter, in which a stable interaction of the first reporter with the second reporter leads to generation of a detectable signal. The first reporter and the second reporter are allowed to bind to the entity, such that binding of the reporters to the entity leads to stable interaction of the first reporter with the second reporter and generation of a signal. The signal is preferably the activation of a cell killing mechanism.