AMPLIFICATION OR OVEREXPRESSION OF MLL SEPTIN-LIKE FUSION (MSF) AND SEPTIN9 AND METHODS RELATED THERETO

摘要

Methods of detecting cancer in a mammal, which methods comprise determining whether or not the mammal has (i) an amplification of a MSF gene, a Septin9 gene, or an ortholog of either of the foregoing, or (ii) an overexpression of a protein or of a nucleic acid molecule, wherein the protein or the nucleic acid molecule is encoded by a MSF gene, a Septin9 gene, or an ortholog of either of the foregoing, wherein amplification of the gene or overexpression of the protein or of the nucleic acid molecule is indicative of cancer; a method of inhibiting a protein encoded by a MSF gene, a Septin9 gene, or an ortholog of either of the foregoing; a method of inducing apoptosis in a cell; methods of testing a candidate drug for efficacy as an anti-cancer drug; and methods for evaluating the progression of cancer in a mammal.