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METHOD FOR THE LINKAGE OF BIFUNCTIONAL CHELATING AGENTS AND (RADIOACTIVE) TRANSITION METAL COMPLEXES TO PROTEINS AND PEPTIDES
METHOD FOR THE LINKAGE OF BIFUNCTIONAL CHELATING AGENTS AND (RADIOACTIVE) TRANSITION METAL COMPLEXES TO PROTEINS AND PEPTIDES
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机译:将功能性螯合剂和(放射性)过渡金属络合物与蛋白质和肽结合的方法
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摘要
The present invention relates to a method for radioactive labeling of a protein or peptide, by providing a protein or peptide having at least one glutamine or lysine residue; adding a metal chelating agent having at least one lysine or glutamine residue, respectively, which metal chelating agent is optionally complexed with a radioactive or paramagnetic metal; reacting the protein or peptide and metal chelating agent in the presence of a transglutaminase to obtain a protein or peptide with a metal chelating group covalently bound thereto, and optionally complexing the metal chelating group with a radioactive or paramagnetic metal. The invention also relates to proteins and peptides thus labeled and to proteins and peptides that have been coupled to a metal chelating agent but not yet labeled.
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