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GLYCEROPHOSPHOCHOLINE AND ITS DERIVATIVES FOR MEDICAL IMAGING NEUROPSYCHIATRIC DISORDERS
GLYCEROPHOSPHOCHOLINE AND ITS DERIVATIVES FOR MEDICAL IMAGING NEUROPSYCHIATRIC DISORDERS
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机译:磷脂酰胆碱及其衍生物对医学影像神经生理紊乱的影响
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摘要
Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the beta-turn of beta amyloid (Abeta) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.
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