SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES

摘要

Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4-substituted 2-oxo-3-butenyl ester and converting the resulting ester to an amide. Additionally disclosed is a method for the preparation of 4 substituted 2 oxo-3 butenoic esters.