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MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME
MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME
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机译:表达共享免疫原性黑色素抗原的黑色素细胞系及其使用方法。
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摘要
The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a cytokine relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogeneic and is not MHC-matched to the host.
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