Objective: To observe the expression of the A melano-ma antigen (MAGE), G melanoma antigen(GAGE) and B melanoma antigen (BAGE) genes inhuman hepatocellular carcinoma cell lines.Methods: The MAGE-1, MAGE-3, GAGE1-8,GAGE1-2 and BAGE mRNA lever in hepatocellularcarcinoma cell lines SMMC-7721, QQY-7701, BEL-7402 were studied by reverse transcription polymer-ase chain reaction and were compared with biopsiedliver tissues.Results: MAGE-1 and BAGE mRNA were expressedin SMMC-7721, MAGE-3 and BAGE in QGY-7701,MAGE-1 and GAGE1-2 in BEL-7402. None of thesegenes was expressed in biopsied liver tissues.Conclusions: MAGE-1, MAGE-3, GAGE1-8,GAGE1-2 and BAGE were expressed in hepatocellu-lar carcinoma cell lines, respectively. These tumor-specific antigens can be used as molecular markersand possible targets of immunotherapy for patientswith hepatocellular carcinoma.
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