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Process for purifying pravastin sodium from a fermentation broth
Process for purifying pravastin sodium from a fermentation broth
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机译:从发酵液中纯化普伐他汀钠的方法
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摘要
A process for purifying pravastatin sodium comprising the steps of:a. clarifying a fermentation broth containing pravastatin sodium to obtain a clear solution; and adjusting the clear solution to be basic having pH value ranging from pH 10∼13;b. adsorbing the pravastatin sodium with non-ionic resin; eluting the pravastatin sodium by water-soluble organic solvent; and forming a concentrate of pravastatin sodium;c. treating the concentrate with water-soluble anti-solvent or inorganic salt to form a precipitate of pravastatin sodium; andd. recrystallizing the precipitate for making pravastatin sodium crystal with high purity and high yield.展开▼