HETEROCYCLYLMETHYLPIPERIDINES AND -PIPERAZINES POSSESSING AFFINITY AT 5HT-1 TYPE RECEPTORS

摘要

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CHSUB2 /SUBor oxygen and is a single bond; or X is nitrogen, Y is CHSUB2 /SUBand is a single bond; R 1 is halogen, cyano, or CSUB1-6 /SUBalkoxy; a is 0,1, 2 or 3 ; b is 0 or 1 ; R 2 is hydrogen, CSUB1-6 /SUBalkyl, CSUB1-6 /SUBalkanoyl, fluoroCSUB1-6 /SUBalkanoyl, CSUB1-6 /SUBalkylsulfonyl, fluoroCSUB1-6 /SUBalkylsulfonyl, carbamoyl, CSUB1-6 /SUBalkylcarbamoyl or arylCSUB1-6 /SUBalkyl; and R 3 , together with the nitrogen atom to which it is attached, forms an optionally substituted 5 to 7 membered heterocyclic group fused to the benzene ring. Methods of preparing the compounds and uses of the compounds in therapy, in particular for a CNS disorder such as depression or anxiety, are also disclosed.