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CAR LIGAND-BINDING DOMAIN POLYPEPTIDE CO-CRYSTALLIZED WITH A LIGAND, AND METHODS OF DESIGNING LIGANDS THAT MODULATE CAR ACTIVITY
CAR LIGAND-BINDING DOMAIN POLYPEPTIDE CO-CRYSTALLIZED WITH A LIGAND, AND METHODS OF DESIGNING LIGANDS THAT MODULATE CAR ACTIVITY
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机译:与配体共结晶的汽车配体结合域多肽,以及设计可调节汽车活性的配体的方法
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摘要
The present invention provides a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide. Also provided is a crystalline form of a substantially pure constitutive androstane receptor (CAR) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the present invention and methods for identifying and designing CAR ligands and modulators. Also provided are scalable three-dimensional configurations of points and computer readable storage media containing digitally encoded structural data
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