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IDENTIFICATION AND USE OF COFACTOR INDEPENDENT PHOSPHOGLYCERATE MUTASE AS A DRUG TARGET
IDENTIFICATION AND USE OF COFACTOR INDEPENDENT PHOSPHOGLYCERATE MUTASE AS A DRUG TARGET
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机译:识别和使用非胰岛素系数的蔗糖突变体作为药物靶标
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摘要
Present embodiments of the invention describe computational methods for performing a systematic, genome-wide search for novel drug targets in pathogenic organisms for example, the human filarial parasites. Cofactor independent phosphoglycerate mutase (iPGM) was identified by this search as a candidate target for identifying therapeutic agents for use in treating animal or plant subjects infected with parasitic nematodes, microbial pathogens including microsporidia, fungi etc. A consensus amino acid or nucleotide sequence that characterizes iPGM is further provided.
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