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Identification and use of cofactor independent phosphoglycerate mutase as a drug target for pathogenic organisms and treatment of the same
Identification and use of cofactor independent phosphoglycerate mutase as a drug target for pathogenic organisms and treatment of the same
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机译:辅因子非依赖性磷酸甘油酸突变酶的鉴定和使用作为致病生物的药物靶标及其治疗
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摘要
Present embodiments of the invention describe computational methods for performing a systematic, genome-wide search for novel drug targets in pathogenic organisms for example, the human filarial parasites. Cofactor independent phosphoglycerate mutase (iPGM) was identified by this search as a candidate target for identifying therapeutic agents for use in treating animal or plant subjects infected with parasitic nematodes, microbial pathogens including microsporidia, fungi etc. A consensus amino acid or nucleotide sequence that characterizes iPGM is further provided.
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