THERAPEUTIC, SCREENING AND DIAGNOSTIC METHODS BASED ON THE EFFECT OF CB1 RECEPTOR MODULATION ON LYMPHOPROLIFERATIVE DISORDERS.

摘要

The invention provides use of a compound capable of modulating CB1 receptor signaling, or of a polypeptide with a biospecific affinity for the CB1 receptor, for the preparation of a medicament for treatment of a lymphoproliferative disorder involving cells with abnormal CB1 receptor function. Furthermore, the invention provides methods for identification of a compound capable of modulating CBI receptor signaling, a method for the diagnosis of a lymphoproliferative disorder involving cells with abnormal CBI receptor function in a subject, a method for treatment of a lymphoproliferative disorder involving cells with abnormal CB1 receptor function, and a method for elimination of malignant lymphocytes from a cell population.