NUCLEAR RECEPTOR-BASED DIAGNOSTIC, THERAPEUTIC, AND SCREENING METHODS

摘要

The present invention features nuclear receptor polypeptides, polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the nuclear receptor polypeptides and polynucleotides of the invention, and for treating conditions associated with nuclear receptor dysfunction with the nuclear receptor polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate nuclear receptor activity or levels.