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HEDGEHOG SIGNALING IN PROSTATE REGENERATION NEOPLASIA AND METASTASIS
HEDGEHOG SIGNALING IN PROSTATE REGENERATION NEOPLASIA AND METASTASIS
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机译:前列腺再生新陈代谢和转移中的刺猬信号
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摘要
Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a prostate tumor to treatment with an Hh pathway antagonist.
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