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SCREENING METHOD FOR DETERMINING INDIVIDUALS AT RISK OF DEVELOPING DISEASES ASSOCIATED WITH DIFFERENT POLYMORPHIC FORMS OF WILDTYPE P53
SCREENING METHOD FOR DETERMINING INDIVIDUALS AT RISK OF DEVELOPING DISEASES ASSOCIATED WITH DIFFERENT POLYMORPHIC FORMS OF WILDTYPE P53
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机译:确定野生型P53多态性与疾病发展有关的个体风险的筛选方法
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摘要
The present invention relates to a screening method to identify individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53; which comprises the steps of: a) obtaining a biological sample from said patients; and b) determining the presence of p53pro or p53arg wildtype alleles in said sample; wherein the allele pattern of patients selected from the group consisting of p53pro/p53pro, p53arg/p53arg and p53pro/p53arg are indicative of a risk factor for developing disease associated with different polymorphic forms of wildtype p53. Notably, individuals who are p53arg/arg are at greater risk of developing pathologies associated with human papillomavirus infections, including cervical cancer.
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