SCREENING METHOD FOR DETERMINING INDIVIDUALS AT RISK OF DEVELOPING DISEASES ASSOCIATED WITH DIFFERENT POLYMORPHIC FORMS OF WILDTYPE P53

摘要

PPROBLEM TO BE SOLVED: To provide a screening method to identify individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53. PSOLUTION: The screening method identifies HPV (human papillomavirus)-infected individuals at risk of developing pathologies associated with human papillomavirus infections, including malignant cancer. The screening method comprises the step of determining the presence of p53argSP72/SPwildtype alleles in a biological sample, wherein the allele pattern of p53argSP72/SP/53argSP72/SPin the sample is indicative of a risk factor for developing pathologies associated with human papillomavirus infections, including malignant cancer. PCOPYRIGHT: (C)2010,JPO&INPIT