首页>
外国专利>
CHERKASKY FUSION PROTEINS CONTAINING ANTIBODY-, ANTIGEN- AND MICROTUBULE-BINDING REGIONS AND IMMUNE RESPONSE-TRIGGERING REGIONS
CHERKASKY FUSION PROTEINS CONTAINING ANTIBODY-, ANTIGEN- AND MICROTUBULE-BINDING REGIONS AND IMMUNE RESPONSE-TRIGGERING REGIONS
展开▼
机译:包含抗体,抗原和微管结合区和免疫反应触发区的切尔卡斯基融合蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to the fields of tumour physiology and biotechnology. The object of the invention is to develop effective and selective novel fusion proteins and fusion protein-antibody complexes against various types of leukaemia and solid tumours. Selectivity is achieved by cell-specific or tumour-specific ligands of the fusion proteins or by antibodies of the fusion protein-antibody complexes. Effectiveness is achieved on the one hand by the direct binding of the microtubules or cytoskeleton elements to the microtubule-binding regions and on the other hand by induction, as well as by the reinforcement of the immune reaction by regions that trigger the immune reaction on the target cells.
展开▼